1.
Make your own luck
We like to think we will our success into existence with our own hard work. And yet, so many of us knock wood, consult tarot cards and read horoscopes, or repeat affirmations to manifest our way to happiness.
It feels like our fate often comes down to circumstance and coincidence, maybe even a bit of magic. But we have more power than we think to make ourselves luckier.
Conjure a positive, expansive outlook by creating a “luck diary. Record a good thing that happened that day, or something bad from the past that’s not happening anymore. Since emotions are contagious, your good mood and sense of possibility can rub off on others. Those people could make things happen for you: funding your idea, making an exception in your favour or connecting you with the love of your life.
Next, try eating a new food, watching a movie you wouldn’t normally watch or rearranging your furniture. You’re showing yourself that you’re a flexible person, Wiseman says. Unlucky people tend to see just one way forward. Lucky people set a goal but stay open to various ways of getting there.
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2.
Gene editing for chronic diseases could change the game for health in the future
CRISPR-based therapies just hit another milestone.
In a small clinical trial with 10 people genetically prone to dangerously high levels of cholesterol, a single infusion of the precision gene editor slashed the artery-clogging fat by up to 55 percent. If all goes well, the one-shot treatment could last a lifetime.
The trial, led by Verve Therapeutics, is the first to explore CRISPR for a chronic disease that’s usually managed with decades of daily pills. It also marks the first use of a newer class of gene editors directly in humans. Called base editing, the technology is more precise—and potentially safer—than the original set of CRISPR tools. The new treatment, VERVE-101, uses a base editor to disable a gene encoding a liver protein that regulates cholesterol.
Thought of the Week
It's hard to be reasonable. There are a million tricks the human mind plays on its owner. That's what causes stupidity. Think of how many times you've said to yourself, 'Why in the hell did I do that?'
People who say they are rational [should] know how things work, what works and what doesn't, and why. That's rationality. It doesn't help if you just know what's worked before, because if you know why, then you'll be better at it. (2)
Both Warren and I feel it's our moral duty to be as rational as we can possibly be. A lot of people who are brilliant in some ways tend to make these utterly asinine decisions in other ways. We both tend to collect the asininities of the world in a kind of checklist. And we try to avoid everything on the checklist.
~ Charlie Munger
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